St. Louis to Caruthersville
Mile 93.0 - 93 - 88.5 LBD Wilkinson Island Middle Miss NWR
93 - 88.5 LBD Wilkinson Island Middle Miss NWR The 2,532-acre Wilkinson Island Division is the largest and southernmost division of the Middle Miss National Wildlife Refuge. It is located 37 miles north of Cape Girardeau, Missouri, in Jackson County, Illinois, and Perry County, Missouri (River Miles 88.